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apalutamide will minimize the extent or impact of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a solid CYP2C19 inducer, with medications which might be CYP2C19 substrates may end up in reduced exposure to those medications.tazemetostat will lower the level or outcome of dia